Scientists from the North Caucasus Federal University have been developing a cure for COVID-19, but as a result, it turned out to be much more effective against cancer. Researchers from the Faculty of Chemistry and Pharmacy of the Stavropol University have synthesized active substances that will help fight neuroblastoma, one of the most dangerous types of cancer.
Scientific developments were carried out under the guidance of professors of the Department of Organic and Analytical Chemistry Nikolai and Alexander Aksenovs together with scientists from the University of Texas. Stavropol students took part in the search for chemical compounds for the treatment of COVID-19. The research was carried out with grants from the Russian Foundation for Basic Research and the US National Institutes of Health.
As noted by the scientists, development is of great importance for obtaining active compounds from available starting materials. This will reduce the cost of therapy for cancer patients.
In this work, we use a method discovered in 2010 and named after the developer “Aksenov’s reaction”. “It is based on the principle of introducing an amino group into an aromatic substance and is very promising,” explained Alexander Aksenov, Doctor of Chemistry.
According to the press service of the university, scientists of the Faculty of Chemistry and Pharmacy for many years have been engaged in the synthesis of substances with high biological activity against socially significant diseases. Among them are viral infections and intractable cancers.
Last year, researchers found new compounds against glioblastoma and melanoma. These agents not only stop the spread of cancer in cells, but also repair tissue damaged by the disease. Promising developments have formed a scientific base that allows the creation of new generation drugs.
An article about the results of research by Stavropol and Texas scientists was published in the journal of the British Royal Chemical Society “Organic & Biomolecular Chemistry”. The study of the toxic properties of the obtained compounds continues. The possibility of patenting the development is being considered.