A new approach to dealing with the corona virus – health and medical news

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During infection with the corona virus, the virus reaches the infected person’s body systems, penetrates cells, multiplies and spreads to various tissues.

At this time the virus is doing its best to evade detection by the immune system, and the corona virus seems to excel in this in a special way relative to the average virus.

In some people, especially those who later develop complications, the virus manages to escape detection and multiply unhindered for a period of a week or more.

Once the virus is detected, a race begins between the immune system, which activates a variety of means to eliminate it – activating thousands of genes and producing hundreds of proteins and hormones, which are responsible for activating alarm mechanisms, mobilizing reserves and reserves, and attacking the virus directly and indirectly. As much as possible and spread itself further by infecting more people.

Four researchers – Dr. Oren Kolodny from the Department of Ecology, Evolution and Behavior and Dr. Michael Berger from the Faculty of Medicine at the Hebrew University, Dr. Yoav Ram from the Efi Arazi School of Computer Science at IDC Herzliya, and Prof. Marcus Feldman from Stanford University – decided to offer an original approach. , But simple, which may help deal with the corona virus.

Their scientific hypothesis was published in the journal Open Biology Under the heading “A New Perspective to Deal With SARS-CoV-2Researchers hope the article will spark a discussion in the medical and academic community, which will lead to clinical trials examining the new approach. The idea put forward by researchers is simple. They claim the way to win the race is to get out early – it may not be fair. In competitive sports, but in fighting a global epidemic the move is legitimate.

The goal is to make the immune system think it is under attack even before it encounters the virus, which will cause it to race, arm itself and get organized, and when the virus arrives it will quickly recognize it before it has spread, and attack it effectively.

The result may be a period of shortened illness and a reduced risk of complications that require hospitalization or lead to a life-threatening condition. Furthermore, the researchers point out that even if the approach is used only in relation to young adults who are not in a risk group and most of whom were only asymptomatically ill even if they were infected, this will be of great importance as early stimulation of the immune system will significantly shorten the duration. Other contagious.

So how do you make the immune system think it’s under attack before the real attack begins? It turns out that Western medicine excels at this – every routine vaccine we get, for example a polio vaccine, the pentavalent vaccine, or a flu vaccine, is based on the immune system being activated in two stages. In the first stage, which occurs immediately after vaccination, general mechanisms are activated against viruses wherever they are. In the second stage, about a week after the vaccine is given, specific mechanisms go into action against the virus against which the vaccine is developed (including an immune memory that will be useful if and when the virus appears). In terms of the immune system, in the period of time that takes between a few days and weeks, she was at war with a real virus for everything. The researchers estimate that if the corona virus is infected during this time, the system will detect and kill it quickly and efficiently..

The question arises what is the connection between excitation against the polio virus, for example, and excitation against corona? After all, the immune system is specific, and the whole idea of ​​the vaccine is to create a specific immune memory against the virus for which the vaccine is intended. In fact, in fighting a virus, the winning blow – the one that finally kills the invading virus – is often given by the adaptive immune system, the one that learns to recognize specific antigens. But much of the fight against viruses, perhaps even the vast majority, is conducted through proteins and hormones that are not specific to the specific disease, but work against a broad spectrum of viruses, or are responsible for communicating the immune system within itself and with various body systems to mobilize or create the necessary resources. The desired conditions in favor of effective fighting of the virus. Many of these will go into action in response to the flu vaccine, for example, and if within a few weeks of the vaccine infection occurs in the corona, some of them will still be recruited, mobilized, and ready for action that will eliminate the corona effectively and quickly..

The researchers emphasize that the proposal at this stage is only a hypothesis, which requires careful examination. It should be ensured, for example, that the early stimulation does not have the opposite effect – that the immune system will be exhausted and weakened when the corona virus itself arrives, or alternatively be so stimulating that the overreaction that occurs when the corona virus arrives will cause severe damage in itself.

According to the researchers, “Our article is intended to provoke discussion in the medical and academic community, and we hope that it will be followed by clinical trials examining the new approach we offer. Its great potential lies in the fact that it is simple and well-established and well-researched.” It would not be harmful for any adult to get their impulse shot anyway.It is important to emphasize, we really do not recommend people to try to stimulate their immune systems independently. We believe there is potential here, and hope it will be tested in the near future“.

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